Immunisation

What is immunisation?

For certain infectious diseases like measles or mumps, once a person has had them and recovered, they are almost certain never to catch that disease again.

This is because when you get an infectious disease your body makes antibodies against that disease, which means that if you are ever exposed to it again, the antibodies in your blood will kill off the 'bugs' before they have any effect.   

A paediatrician explains how immunisation works.

A paediatrician explains how immunisation works.

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Immunisations work on the same kind of principle that by injecting a very small amount of the disease - so small or inactive that it will not give you the disease itself, a person will develop antibodies and therefore an immunity to the disease and are very, very unlikely to suffer the disease itself, or if they do, it will be in a very mild form. Over the years many vaccines have been developed against infectious diseases. These vaccines contain either minute quantities of the active disease or contain the bug giving the disease in a very modified form so that it means that your body creates the antibodies that you need but that you don't actually get the disease itself. In this way you get all the protection that you should have without having the illness.

In the UK, babies and young children are routinely immunised against several different infectious diseases.

Immunisation of children in the UK is not compulsory as it is in some other countries, so parents choose whether or not to have their child immunised.  However, there are very good reasons why we immunise children (see 'Why do we immunise?').   

Designing a vaccine and vaccine safety in clinical trials

Safety is always the primary concern in designing a vaccine and is the first thing that is tested when a new vaccine is going through clinical trials. All potential problems of any kind are thoroughly investigated and excluded before clinical trials for the vaccine are started with children.

The standards and regulations for testing and monitoring vaccines are very high, and they must pass through various stages and phases of rigorous trials, testing, and research before they are approved for use. It often takes many years for a vaccine to make it through testing and be approved, and it is still closely monitored after it has been approved. 

In the final phase of testing, and after they have been approved for safe use, data is collected from a wide range of people using it to check on and monitor any rare side effects. These effects are often studied by researchers by having parents keep diaries of their children's symptoms after vaccination, if there are any.  

By the time that a vaccine is ready to be given routinely to all children, there will be evidence of the vaccine’s safety from studies involving tens of thousands of children, and this evidence will have been examined extremely carefully by national and international drug safety committees. 

A paediatrician talks about the safety of vaccines.

A paediatrician talks about the safety of vaccines.

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Safety is always the primary concern in designing a vaccine, and is the first thing that is tested when a new vaccine is going through clinical trials. All potential problems of any kind are thoroughly investigated and excluded before clinical trials are started on children. Side effects are studied in the clinical trials, often by parents keeping diaries of their children's symptoms after vaccination - if there are any. By the time that a vaccine is ready to be given routinely to all children, there will be evidence of the vaccines safety from studies involving tens of thousands of children, and this evidence will have been examined extremely carefully by national and international drug safety committees. For more information on the safety of vaccines have a look at the 'Questions and Answers' section on this site.

As well as containing a very small amount live or modified amounts of the bugs causing the disease, vaccines are also preserved with small amounts of things such as formaldehyde, aluminium and antibiotics. Formaldehyde converts the bacterial toxins into “toxoids” which are harmless but give immunity against the dangerous toxins which may be produced when you actually get the bad form of the infectious diseases. This is an entirely safe procedure which really works. Also every batch of toxoid vaccines is tested to make sure that they have been made absolutely safe, and that the preservatives in the vaccines are in very, very low dosages.

The immunisation programme in the United Kingdom aims to give children the best possible protection against the widest range of infectious diseases in the safest way possible.

The schedule that the immunisation programme recommends for children for routine vaccination is as follows: 

Age when vaccine is recommended What vaccine is given No. of 
injections
Pregnant mothers
Whooping cough (pertussis)

Pregnant mothers are offered a whooping cough vaccination from 16 weeks of pregnancy to help protect the baby from developing whooping cough in their first few weeks of life. Babies are not vaccinated against whooping cough until they are 2 months/8 weeks old.

& Respiratory syncytial virus (RSV) from 28 to 26 weeks of pregnancy 

& Influenza (inactivated flu vaccine) at any stage of pregnancy during flu season 

One injection

 

 

 

 

 

 

One injection

 

One injection

 

2 months/8 weeks old
Diphtheria, Tetanus, Pertussis (whooping cough), polio, Haemophilus influenzae type b (Hib), and hepatitis B (DTaP/IPV/Hib/HepB) (1st dose);
also known as the 6-in-1 vaccine

 
& Rotavirus gastroenteritis (Rotavirus) (1st dose)

& Meningococcal group B (Men B) (1st dose)

One injection


 
 
 

Oral vaccine


One injection

 3 months/12 weeks old

Diphtheria, tetanus, pertussis (whooping cough), polioHaemophilus influenzae type b (Hib), and hepatitis B (DTaP/IPV/Hib/HepB) (2nd dose); 
also known as the 6-in-1 vaccine

Pneumococcal conjugate (PCV) (1st dose)

& Rotavirus gastroenteritis (Rotavirus) (2nd dose)

One injection
 

 

 

 

One injection
 

Oral vaccine

4 months/16 weeks old

Diphtheria, tetanus, pertussis (whooping cough), polio, Haemophilus influenzae type b (Hib), and hepatitis B (DTaP/IPV/Hib/HepB) (3rd dose); 
also known as the 6-in-1 vaccine

& Meningococcal B (Men B) vaccine (2nd dose)

One injection

 

 

 


One injection

Between 12 to 13 months/one year old (given on or after the child's first birthday)

Meningococcal group C (Men C) vaccine (1st dose) & Haemophilus influenzae type b booster (4th dose)

& Pneumococcal (PVC) booster (2nd dose)

& Measles/Mumps/Rubella (MMR) (1st dose)

& Meningococcal B (Men B) booster (3rd dose)

One injection
 
 
 
One injection
 
 
One injection
 
 
One injection
Eligible paediatric age group, each year from September Influenza vaccine (flu jab) One injection
3 years, 4 months or soon after
Diphtheria, tetanus, pertussis (whooping cough), and polio (dTaP/IPV)
also known as the 4-in-1 or pre-school booster

& Measles, mumps and rubella (MMR) booster (2nd dose)

One injection
 
 

 

One injection

Boys and girls aged 12 -13 years Human Papilloma virus (HPV)  Three injections
14 years old (school year 9)
Tetanus, diphtheria, and polio (Td/IPV);
also known as the 3-in-1 or teenage booster

& Meningococcal groups A,C,W, and Y (MenACWY)
One injection
 
 
 
One injection
19-25 years (first-time students only)

Meningococcal groups A,C,W, and Y (MenACWY)

& Measles, mumps and rubella (MMR) (2 doses)

& Human Papilloma virus (HPV) 

One injection
 
 
One injection
 
 
One injection

For more information about routine vaccination/immunisation recommendations, including information about selective immunisation programmes and additional vaccines for individuals with underlying medical conditions, see the information published by the UK Health Security Agency at GOV.UK (see ‘Resources and Information’). 

The immunisation clinics that you will be asked to attend with your baby are run by the general practice (GP) where you and your child are registered. You should receive an appointment letter when your child's immunisation is due.

If you have any questions about your child's immunisations talk to your GP or health visitor. Details of your baby's immunisation schedule will also be available to you in your 'parent held' Child Health Record.

Immunisations for teenagers are usually arranged in schools.

Last reviewed: April 2025.
Last updated: April 2025.

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